PE-22-28 10mg

PE-22-28 10mg

PE-22-28 is a synthetic analog of Spadin, a short peptide derived from the TREK-1 potassium channel propeptide. Spadin and its analogs have been identified as potential fast-acting antidepressants through TREK-1 channel blockade and subsequent BDNF upregulation.

Research into PE-22-28 has focused on its antidepressant-like effects in forced swim tests and tail suspension models, with proposed mechanisms including TREK-1 inhibition, hippocampal neurogenesis, and serotonergic pathway modulation.

Specifications: 10mg lyophilized powder | Purity ≥99% (HPLC) | MW ~900 g/mol | Store at −20°C

For Research Use Only. Not for human or veterinary use. This product is intended solely for in vitro and laboratory research. Not approved by the FDA. Not a drug, food, or cosmetic. Keep out of reach of children.